PKA signaling drives mammary tumorigenesis through Src.
Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R.
Oncogene (2014). doi: 10.1038/onc.2014.41 [PubMed]

The integrated landscape of driver genomic alterations in glioblastoma.
Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A.
Nat Genet. 45, 1141-1149 (2013). [PubMed]

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Privé GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A.
Cell Rep. 4, 578-588 (2013). [PubMed]

Systemic ceramide accumulation leads to severe and varied pathological consequences.
Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA.
EMBO Mol Med. 5, 827-842 (2013). [PubMed]

Crystal structure of KLHL3 in complex with Cullin3.
Ji AX, Privé GG.
PLoS One. 8(4):e60445 (2013). [PubMed] [4HXI]

Detergent-mediated protein aggregation.
Neale C, Ghanei H, Holyoake J, Bishop RE, Privé GG, Pomès R.
Chem Phys Lipids 169, 72-84 (2013). [PubMed]

Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
Errington WJ, Khan MQ, Bueler SA, Rubinstein JL, Chakrabartty A, Privé GG.
Structure (2012). [PubMed] [4EOZ]

Structure of saposin A lipoprotein discs.
Popovic K, Holyoake J, Pomès R, Privé GG.
PNAS 109, 2908-2912 (2012). [PubMed] [4DDJ]

PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.
Cuesta-Seijo JA, Neale C, Khan MA, Moktar J, Tran CD, Bishop RE, Pomès R, Privé GG.
Structure 18, 1210-1219 (2010). [PubMed] [PDF] [Supporting Information] [3GP6]

Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.
Cirak S, von Deimling F, Sachdev S, Errington WJ, Herrmann R, Bönnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Privé GG, Hannink M, Nürnberg P, Voit T.
Brain 133, 2123-2135 (2010). [PubMed]

Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.
Stogios PJ, Cuesta-Seijo JA, Chen L, Pomroy NC, Privé GG.
J Mol Biol.
400, 983-997 (2010). [PubMed] [3M5B] [3M52]

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.
Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A.
Cancer Cell 17, 400-411 (2010). [PubMed] [3LBZ]

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.
Senisterra GA, Ghanei H, Khutoreskaya G, Dobrovetsky E, Edwards AM, Privé GG, Vedadi M.
J Biomol Screen. 15, 314-320 (2010). [PubMed]

Lipopeptide detergents for membrane protein studies.
Privé GG.
Curr Opin Struct Biol. 19, 379-385 (2009). [PubMed]

Crystal structure of a self-assembling lipopeptide detergent at 1.20 Å.
Ho DN, Pomroy NC, Cuesta-Seijo JA and Privé GG.
PNAS 105, 12861-12866 (2008). [PubMed] [3CAY] [3CBA]

Protecting role of cosolvents in protein denaturation by SDS: a structural study.
Michaux C, Pouyez J, Wouters J and Privé GG.
BMC Struc. Biol. 8, 29 (2008). [PubMed] [3B6L] [3B72]

Crystal structures of the human ceramide activator protein D.

Popovic K and Privé GG.
Acta Cryst D 64, 589-594 (2008). [PubMed] [PDF] [3BQP] [3BQQ]

Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas.
Parekh SS, Privé GG and Melnick A.
Leukemia and Lymphoma.
49, 874-882 (2008). [PubMed] [PDF]

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer.

Ghetu AF, Corcoran CM, Cerhietti L, Bardwell J, Melnick A and Privé GG.
Mol. Cell
29, 384-391 (2008). [PubMed] [PDF] [3BIM]

Refolding SDS-denatured proteins by the addition of amphipathic cosolvents.
Michaux C, Pomroy NC and Privé GG.
J. Mol. Biol. 375, 1477-1488 (2008). [PubMed] [PDF]

Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C.
Alattia JR, Shaw JE, Yip CM, Privé GG.
PNAS 104, 17388-17393 (2007). [PubMed] [PDF]

Gauging a Hydrocarbon Ruler by an Intrinsic Exciton Probe.
Khan MA, Neale C, Michaux C, Pomes R, Privé GG, Woody RW, Bishop RE.
46, 4565-4579 (2007). [PubMed]

Detergents for the stabilization and crystallization of membrane proteins.
Privé GG.
Methods 41, 388-397 (2007). [PubMed]

Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.
Stogios PJ, Chen L and Privé GG.
Protein Sci. 16, 336-342 (2007). [PubMed] [2NN2]

Structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone cnidopus japonicus.
Chan MC, Karasawa S, Mizuno H, Bosanac I, Ho D, Privé GG, Miyawaki A, Ikura M.
J Biol Chem. 281, 37813-37819 (2006). [PubMed] [2IB5] [2IB6]

Direct Visualization of Saposin Remodelling of Lipid Bilayers.
Alattia JR, Shaw JE, Yip CM and Privé GG.
J Mol Biol. 362, 943-953 (2006). [PubMed]

Crystal structures of saposins A and C.
Ahn VE, Leyko P, Alattia JR, Chen L and Privé GG.
Protein Sci. 15, 1849-1857 (2006). [PubMed] [2DOB] [2GTG]

Mechanisms of antimicrobial peptide action: studies of indolicidin assembly at model membrane interfaces by in situ atomic force microscopy.
Shaw JE, Alattia JR, Verity JE, Privé GG and Yip CM.
J Struct Biol. 154, 42-58 (2006). [PubMed]

Specific peptides for the therapeutic targeting of oncogenes.
Privé GG and Melnick A.
Curr Opin Genet Dev. 16, 71-77 (2006). [PubMed]

Sequence and structural analysis of BTB proteins.
Stogios PJ, Downs GS, Jauhal J, Nandra S and Privé GG.
Genome Biology 6, R82 (2005). [PubMed]

Molecular Models of Lipopeptide Detergents: Large Coiled-Coils with Hydrocarbon Interiors.
Kelly E, Privé GG, Tieleman DP.
J. Am. Chem. Soc. 46, 2254-2264 (2005). [PubMed]

A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A.
Norris AJ, Whitelegge JP, Yaghobian A, Alattia JR, Privé GG, Toyokuni T, Sun H, Brooks MN, Panza L, Matto P, Compostella R, Remmel N, Klingenstein R, Sandhoff K, Fluharty C, Fluharty A, Faull KF.
J. Lipid Res. 46, 2254-2264 (2005). [PubMed]

The BACK domain in BTB-kelch proteins.
Stogios PJ and Privé GG.
Trends in Biochemical Sciences 29, 634-637 (2004). [PubMed]

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.
Polo JM, Dell'oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, Privé GG, Licht JD, Melnick A.
Nature Medicine 10, 1329-1335 (2004). [PubMed]

A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin.
Ahn VE, Lo EI, Engel CK, Chen L, Hwang PM, Kay LE, Bishop RE, Privé GG.
23, 2931-2941 (2004). [PubMed] [PDF] [1THQ]

Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain.
Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang C, Mayer S, Takahashi S, Licht JD, Privé GG.
Molecular Cell 12, 1551-1564 (2003). [PubMed] [1R28] [1R29] [1R2B]

Characterization of a recombinant molecule covalently indistinguishable from human cerebroside-sulfate activator protein (CSAct or Saposin B).
Whitelegge JP, Ahn V, Norris AJ, Sung H, Waring A, Stevens RL, Fluharty CB, Prive G, Faull KF, Fluharty AL.
Cell Mol. Biology 49, 799-807 (2003). [PubMed]

Lipopeptide Detergents Designed for the Structural Study of Membrane Proteins.
McGregor CL, Chen L, Pomroy NC, Hwang P, Go S, Chakrabartty A and Privé GG.
Nature Biotechnology 2, 171-176 (2003). [PubMed]

Crystal structure of saposin B reveals a dimeric shell for lipid binding.
Ahn VE, Faull KF, Whitelegge JP, Fluharty, AL and Privé, GG.
Proc. Natl. Acad. Sci. USA 100, 38-43 (2003). [PubMed] [1N69]

Expression, purification, crystallization and preliminary X-ray analysis of recombinant human saposin B.
Ahn VE, Faull KF, Whitelegge JP, Higginson J, Fluharty AL and Privé GG.
Protein Expression and Purification 27, 186-193 (2003). [PubMed]

Solution structure and dynamics of the outer membrane enzyme PagP by NMR.
Hwang PM, Choy WY, Lo EI, Chen L, Forman-Kay JD, Raetz CR, Privé GG., Bishop RE, Kay LE
Proc Natl Acad Sci U S A. 99, 13560-5 (2002). [PubMed] [1MM4] [1MM5]

Stability of the lactose permease in detergent solutions.
Engel CK, Chen L and Privé GG.
Biochim Biophys Acta. 1561, 47-56 (2002). [PubMed]

Insertion of carrier proteins into hydrophilic loops of the Escherichia coli lactose permease.
Engel CK, Chen L and Privé GG.
Biochim Biophys Acta. 1561, 38-46 (2002). [PubMed]

Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.
Melnick A, Carlile G, Ahmad KF, Kiang CL, Corcoran C, Bardwell, Privé GG, Licht JD.
Mol. Cell. Biol. 20, 6550-6567 (2002). [PubMed]


See Pubmed.